Friday, July 1, 2011

Is An Adult Beverage Too Much to Ask For??

Knowing that this is over, I was looking forward to enjoying a glass of wine tonight. I woke up this morning before my appointment and POAS...there was a faint line. I knew going into my clinic that my HCG went up. It ended up going from 7.8 to 13.4. Since technically it is an "appropriate" rise, I still must continue all of my medications and proceed as if I were pregnant. My clinic has to cover their ass. I go back Tuesday morning for another level. My RE said today that if it is slowly rising over a period of time, that we will have to intervene. If my level plateaus or shoots up we will have to assume it's ectopic and I will need to be treated with Methotrexate again...more Chemo, ugh! If it is going up but only by a point or two we could always use Misoprostol to induce the miscarriage. Sounds like fun, huh?

After having my blood drawn, my husband and I sat down with my RE for almost an hour. I trust him with my life as he is a straight shooter and he feeds me no bullshit. After this current loss, we can safely assume that my lining is the cause of all of the previous losses. What can you do to fix it? Nothing. He said that it could feasibly take 2 or 3 years for this to work for me, but he truly believes, that if I stay at it, it will happen. He said that we could face more miscarriages or more chemical pregnancies by going forward. He said the length of time that I can do this for is dependent on how I am doing emotionally and mentally, not to mention financially. He did say that the easiest and quickest way for me to have a baby is through surrogacy. I would consider this, but again, I have no family or friends (that currently aren't pregnant) that would do this. He said that as long as a woman has a uterus, she can be a surrogate. I asked him if there was a cut-off age and he said that there really wasn't. He said that some one in their 50's could do this for me. This is the time that I really wish that I had a family. How awesome would it be for someone that you love and are close to give you such an awesome gift. To do surrogacy I will basically go through IVF up until the ER. Once the eggs are removed from my uterus and fertilized with my husband's sperm, they embryos would be transferred back into the surrogate's uterus. The only thing that the surrogate would have to do is use vaginal estrogen and progesterone for a few weeks prior to the transfer and for 10 weeks after.

Since my husband and I don't have anyone in our families that would do this (you just can't ask them) surrogacy is not an option. Since we have no other choice we are going to proceed with more IVF. For my next cycle we will be doing a Agonist/Antagonist Conversion Protocol with Estrogen Priming. I will take BCP for about 8 days or so and add in Lupron. Two days after starting Lupron I stop the BCP. AF should arrive 3-5 days after stopping the BCP. When AF starts the Lupron is stopped and low dose Ganirelix is started along with estradiol valerate injections every third day. High dose Follisitm is then started and 37.5U of Menopur is started 4-5 days later. The "estrogen priming" is continued until more than 50% of my follicles are at least 12mm in size. Follisitm and Menopur are continued until trigger. This protocol was developed for poor responders and those with poor egg quality. In poor responders, Lupron given along with stims can over suppress the ovaries which leads to very poor response. However, Lupron is needed prior to starting stims as the pituitary gland needs to "dump out" all of its FSH and LH. If this is done after the start of AF, egg quality can be affected because of the initial rise in LH and FSH. Lupron is replaced with 1/2 dose Ganirelix at the start of stims so that the risk of over suppression is minimized. Typically the estradiol valerate is started prior to the onset of AF and then discontinued. This will take away the effects it has on the endometrial lining as AF naturally thins your lining and we are trying to thicken mine, not thin it. The estradiol valerate is discontinued early in follicle development so the medication doesn't impact egg quality. There are no guarantees with anything, but this is something that we haven't tried yet.

Along with the above mentioned protocol we are also going to incorporate Nitroglycerin Patches and possibly Neuprogen to help with my lining. The Neuprogen costs about $4000 per cycle and we are not sure if my insurance will cover it. If they won't there is no way that I can afford it. I will also be having an endometrial biopsy prior to the start of stims so that the lining will be damaged in hopes that it will over compensate to repair itself by thickening. Also, when I go back to check my HCG on Tuesday we are going to test my Anti-thyroid Antibody level, and my DHEAS level. Tuesday can't come fast enough!


  1. krystn, i am beyond amazed at your strength and am inspired by your determination.
    i'm so so sorry you are having to deal with this and that it is being drawn out.
    i wish you nothing but the best and a huge glass, no scratch that...huge BOTTLE of wine.

  2. Krystyn,

    I'm glad they are switching you to the A/ACP + E2V protocol. It's the best protocol out there and we had a better response with that than any other protocol. I hope things from this cycle resolve for you soon and you can have some whipped cream beverages. :)

  3. Krystyn,
    I'll say it over and over you are the strongest most determined person I have ever met. I pray that these new changes help you and that you are on your way to your dreams coming true. I'm so sorry for you that this cycle isn't resolved yet and will be praying for it to allow you to move on quickly.
    We used the estrogen priming protocol our last cycle and obviously it was our best cycle ever. So I hope you have the same luck, I'll be here cheering you on all the way. If you need anything at all please let me know. Hugs!